Serdan TDA, Cervantes H, Frank B, Tian Q, Choi CHJ, Hoffmann A, Cohen P, Blüher M, Schwartz GJ, Shamsi F. (2024) Slit3 Fragments Orchestrate Neurovascular Expansion and Thermogenesis in Brown Adipose Tissue. BioRxiv. doi: https://doi.org/10.1101/2024.09.24.613949

Shamsi F#*, Zheng R#, Ho L-L, Chen K*, Tseng Y-H*. (2023) Comprehensive analysis of intercellular communication in thermogenic adipose niche. Communication Biology. PubMed #Equal contribution, *Corresponding author

Selected publications

Shamsi F. Methods for Single Cell Transcriptomic Analysis of Adipose Tissue. Methods Mol Biol. 2023;2662:241-249. PubMed

Angueira AR, Sakers AP, Holman CD, Cheng L, Arbocco M, Shamsi F, Lynes MD, Shrestha R, Okada C, Batmanov K, Susztak K, Tseng YH, Liaw L, Seale P. (2021) Defining the lineage of thermogenic perivascular adipose tissue. Nature Metabolism. 3(4):469-484. PubMed

Wang CH, Lundh M, Fu A, Kriszt R, Huang TL, Lynes MD, Leiria LO, Shamsi F, Darcy J, Greenwood BP, Narain NR, Tolstikov V, Smith KL, Emanuelli B, Chang YT, Hagen S, Danial NN, Kiebish MA, Tseng YH. (2020) CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice. Science Translational Medicine. 26;12(558). PubMed

Shwartz Y, Gonzalez-Celeiro M, Chen CL, Pasolli HA, Sheu SH, Fan S, Shamsi F, Assaad S, Lin E, Zhang B, Tsai PC, He M, Tseng YH, Lin SJ, and Hsu YC. (2020) Cell types promoting goosebumps form a niche to regulate hair follicle stem cells. Cell, 182, 578–593. PubMed

Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE, Darcy J, Huang TL, Kodani SD, Sakaguchi M, Rocha AL, Schulz TJ, Bartelt A, Hotamisligil GS, Hirshman MF, van Leyen K, Goodyear LJ, Blüher M, Cypess AM, Kiebish MA, Spite M, Tseng YH. (2019) 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat. Cell Metabolism, 30(4):768-783. PubMed

Lynes MD, Shamsi F, Sustarsic EG, Leiria LO, Wang CH, Su SC, Huang TL, Gao F, Narain NR, Chen EY, Cypess AM, Schulz TJ, Gerhart-Hines Z, Kiebish MA, Tseng YH. (2018) Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism. Cell Reports, 24(3):781-790. PubMed

Shamsi F, Zhang H, Tseng YH. (2017) MicroRNA Regulation of Brown Adipogenesis and Thermogenic Energy Expenditure. Frontiers in Endocrinology, 8:205. PubMed

Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Bluher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH. (2017) The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nature Medicine, 23(5):631-637. PubMed

Shamsi F, Tseng YH. (2017) Protocols for Generation of Immortalized Human Brown and White Preadipocyte Cell Lines. Methods Mol Biol, 1566:77-85. PubMed

Shamsi F, Parlatto R, Collombat P, Mansouri A. (2014) A genetic mouse model for progressive ablation and regeneration of insulin producing beta-cells. Cell Cycle, 13(24):3948-57. PubMed